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陈一杰(第二临床学院)

陈一杰,博士,副研究员,硕士研究生导师

温州医科大学附属第二医院、育英儿童医院

电话:13868402175

Emailchenyijie@wmu.edu.cn

 

主要教育和工作经历

20116月至20157月,博士研究生,上海交通大学Med-X研究院,古宏晨教授、夏伟梁教授

20158月至201912月,助理研究员,温州医科大学

20166月至20195月,博士后研究员,美国加州大学圣地亚哥分校,张良方教授

2020年至今,副研究员,温州医科大学

 

研究领域

1. 癌症治疗新途径、新方法的开发和应用

2. 仿生纳米医学用于超级细菌的治疗

3. 仿生纳米医学在创伤修复中的应用

 

5年代表性文章:

  1. Chen Y., Zhang Y., Zhuang J, Lee J., Wang L., Fang R., Gao W. and Zhang L. Cell Membrane-cloaked Oil Nanosponges Enable Dual-modal Detoxification (2019). ACS Nano, 2019, 13, 7209-7215.

  2. Yue Zhang, Yijie Chen (co-first author), Christopher Lo, Jia Zhuang, Pavimol Angsantikul, Qiangzhe Zhang, Xiaoli Wei, Zhidong Zhou, Marygorret Obonyo, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang. Inhibition of pathogen adhesion by bacterial out membrane-coated nanoparticles (2019). Angewandte Chemie International Edition, 2019, 58, 11404-11408.

  3. Chen Y., Zhang Y., Chen M., Zhuang J., Fang R., Gao W., Zhang L. Biomimetic Nansponges Suppress In Vivo Lethality Induced by the Whole Secreted Proteins of Pathogenic Bacteria (2019). Small, 15, 1084994.

  4. Yijie Chen, Hongchen Gu, Ding Sheng-zi Zhang, Fan Li, Tengyuan Liu, Weiliang Xia. Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier (2014), Biomaterials, 2014, 35(38), 10058-10069.

  5. Y. Chen, M. Chen, Y. Zhang, J. H. Lee, T. Escajadillo, H. Gong, R. Fang, W. Gao, V. Nizet, L. Zhang*, Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges (2018), Advanced Healthcare Materials, 7(13), 1701366. IF: 6.270 (Journal Cover)

  6. Chen M., Wang L., Wang F., Li F., Xia W., Gu H., Chen Y. Quick Synthesis of A Novel Combinatorial Delivery System of siRNA And Doxorubicin for A Synergistic Anticancer Effect (2019). International journal of Nanomedicine, 2019, 15;14:3557-3569.

  7. Yijie Chen, Xinran Wang, Ting Liu, Ding Sheng-zi Zhang, Yunfei Wang, Hongchen Gu*, Wen Di*, Highly effective anti-angiogenesis via magnetic mesoporous silica based siRNA vehicle targeting the VEGF gene for orthotopic ovarian cancer therapy (2015). International Journal of Nanomedicine, 2015, 10: 2579-2594.

  8. Lin J., Jia C., Wang Y., Jiang S., Jia Z., Chen N., Sheng S., Li S., Jiang L., Xu H., Zhou K., Chen Y. Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress (2019). Drug Design, Development and Therapy, 2019:13 1461-1472.

  9. W. Gao, Y. Chen, Y. Zhang, Q. Zhang, L. Zhang, Nanoparticle-based local antimicrobial drug delivery (2018). Advanced Drug Delivery Reviews. 2018, 127: 46-57.

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